About Phamracogenomics (PGx)

PGx is the study of how your genes may affect your body’s response to certain prescription or over-the-counter medications.

  • Testing includes medications in several categories including those used to treat pain, cardiovascular conditions, psychiatric conditions, diabetes and several others

  • Because it is based on DNA, each result report is individualized for the patient

FAQs

What are the benefits of PGx testing?

  • Reduces adverse drug side effects

  • Identifies possible drug-to-drug interactions

  • Maximizes drug dose response

  • Lifetime utility - because testing is based on DNA, results will be useful for patient’s entire lieftime

What types of medications are inlcuded in Principle Direct PGx testing?

  • Anticoagulant Medications

  • Antirrhythmic Medications

  • Anti-diabetic Medications

  • Cholesterol-Lowering Medications

  • Anti-hypertensive Medications

  • Anticonvulsant Medications

  • Antidepressant Medications

  • Antipsychotic Medications

  • Immunological Medications

  • Steroid Medications

  • Onlcology Medications

  • Pain Management Medications

Should I have a PGx test?

PGx testing can benefit many types of patients but specifically those taking certain pain, cadiovascular, diabetes and psyciatric medications. If you take one or more medication, PGx testing could improve your treatment plan and overall health.

What genes are tested in PGx testing?

Principle Direct PGx panel includes the following genes: APOE, COMT, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, MTHFR, VKORC1, Factor II, Factor V, SLCO1B1

Is it hard to collect a PGx specimen?

PGx specimen collection is convenient and painless using a simple cheek swab. Anyone can collect a PGx specimen and Principle Direct offers testing from the comfort of your own home.