About Cancer Genomics (CGx)

CGx is an assessment of genetic mutations associated with hereditary cancer syndromes.

  • Advancements in human genome mapping has provided the ability to identify inherited genetic mutations inlcuding those which increase cancer risk

  • Certain genetic mutations have been associated with over 50 hereditary cancer syndromes

  • CGx testing can help identify family members at risk for developing cancer

FAQs

What types of cancers are inlcuded in Principle Direct CGx testing?

  • FAP (APC)

  • Bloom Syndrome (BLM)

  • Breast Cancer (BRCA1, BRCA2, PALB2)

  • Ovarian Cancer (BRCA1, BRCA2)

  • Fanconi anemia (FANCC)

  • Lynch Syndrome (MLH1, MSH2, MSH6, PMS2)

  • Cowden disease (PTEN)

  • Li-Fraumeni syndrome (TP53)

Should I have a CGx test?

If you have a family history of cancer caused by genetic mutations, CGx testing may be right for you.

What genes are tested in CGx testing?

Principle Direct CGx panel includes the following genes: APPC, BLM, BRCA1, BRCA2, FANCC, MLH1, MSH1, MSH2, MSH6, PALB2, PMS2, PTEN, TP53